What are Exosomes?
When it comes to cellular repair, our natural stem cell populations are tasked with receiving the biosignals that indicate that damage has occurred and to respond appropriately. They do this by releasing or amplifying biological messages that then direct cells to respond. In some cases, this means cellular remodeling or remodeling of the structural extracellular matrix proteins that hold our cells together and in place, such as collagen and elastin.
When stem cells respond to the “information” they receive, such as excessive UV rays from the sun, these powerful cells release nanosized messages, encapsulated in a lipid bilayer to protect them, known as exosomes.
Exosomes are produced by many many cells types throughout the body and can be thought of like a piece of mail that is addressed by one cell and is sent to another. The exosome is essentially a biological, very small (nano sized) envelope. However, not all exosomes are the same. The cell that produces the exosome and the conditions under which that cell is cultured dictate the type and number of exosomes produced.
So, we don’t want just any exosomes, we want the exosomes with the optimum message from the youngest, healthiest, most optimum cell with the ability to encapsulate and send the most potent healing messages. For this reason, ELEVAl labs uses stem cells isolated from the Wharton’s Jelly portion of the umbilical cord. This powerful MSCs are the youngest, ethically sourced stem cells and are isolated in ultra pure (CGMP grade) conditions and are tested rigorously to ensure quality and safetv.
ELEVAI approaches skincare at a cellular level, isolating the body’s natural regenerative mechanisms to create healthy, youthful skin. The ELEVAl exosome is the hero of skin repair. The nano encapsulated biomolecules promote deep and effective penetration of the product to support the dermis.
The ELEVAI Post Treatment E-Series helps support repair and rejuvenation by recharging the cellular repair pathways that become less effective with age. As the exosomes reach the dermis, they promote and support healthy intercellular communication – signaling the body’s natural healing response. Collagen and elastin synthesis results in rebuilding and replacement of damaged extracellular matrix proteins, while improved blood flow and healthy cell turnover result in epidermal regeneration and gradually reveal rejuvenated, youthful looking skin, from the inside out.
Inflammation and redness are mitigated by proteins that help balance and calm the skin, leaving your skin looking clear and feeling smooth, soft, and refreshed.
MSC exosomes are also shown in the academic literature to be involved in the induction of angiogenesis, inhibition of fibrosis, enhancing of the neuronal survival and differentiation, stimulation of extracellular matrix remodeling, abrogation of local inflammation response, and also the regulation of immune cells activities.
Liu, Shi-Jie et al. “Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Ameliorate HaCaT Cell Photo-Aging.” Rejuvenation research vol. 24,4 (2021): 283-293. doi:10.1089/rej.2020.2313
Kirkham, Aidan M et al. “Mesenchymal stromal cells as a therapeutic intervention for COVID-19: a living systematic review and meta-analysis protocol.” Systematic reviews vol. 10,1 249. 15 Sep. 2021, doi:10.1186/s13643-021-01803-5
Cha, Hyeonin et al. “Stem Cell-Derived Exosomes and Nanovesicles: Promotion of Cell Proliferation, Miaration, and Anti-Senescence for Treatment of Wound Damage and Skin Ageing.” Pharmaceutics vol. 12,12 1135. 24 Nov. 2020, doi:10.3390/pharmaceutics12121135
Qiu G, Zheng G, Ge M, Wang J, Huang R, Shu Q, et al. Functional proteins of mesenchymal stem cell-derived extracellular vesicles. Stem Cell Res Ther. 2019:10:1-11.